| Primary Identifier | IPR038829 | Type | Family |
| Short Name | Leukosialin |
| description | Leukosialin (CD43, sialophorin) is a large sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes) []. It is involved in leukocyte adhesion and migration [, ]. Leukosialin interacts with the T cell receptor (TcR) to initiate signaling events during T cell priming []. The CD43 signaling pathway induces the expression of IFN-gamma by effector CD4+ T cells (Th, helper T cells) and to a lesser extent CD8+ T cells (Tc, cytotoxic T cells) []. Besides its role in progression of the T cell differentiation program, CD43 plays a role in T cell homing from lymphoid organs to peripheral tissues [, , ]. |
