| Primary Identifier | IPR034494 | Type | Domain |
| Short Name | TIAR_RRM2 |
| description | This entry represents the RNA recognition motif 2 (RRM2) of nucleolysin TIAR (TIA-1-related protein).TIAR is a cytotoxic granule-associated RNA-binding protein that shows high sequence similarity with TIA-1 []. TIAR plays a critical role in transcriptional and posttranscriptional regulation of gene expression []. It binds to target mRNA and DNA via its RNA recognition motif (RRM) domains and is involved in both splicing regulation and translational repression via the formation of stress granules []. TIAR is composed of three N-terminal highly homologous RNA recognition motifs (RRMs) and a glutamine-rich C-terminal auxiliary domain containing a lysosome-targeting motif. Its RRMs are involved in binding to U-rich RNA, but with unequal contributions. RRM2 of TIAR is the major RNA- and DNA-binding domain []. |
