| Primary Identifier | IPR034509 | Type | Domain |
| Short Name | PUB1_RRM1 |
| description | This entry represents the RNA recognition motif 1 (RRM1) of yeast protein Pub1.Pub1 (poly(U)-binding protein) is a yeast homologue of the mammalian ELAV-like proteins HuR and TIA-1/TIAR. Pub1 regulates cellular mRNA decay, and it also regulates gene expression by diverse posttranscriptional mechanisms []. It has been identified as both a heterogeneous nuclear RNA-binding protein (hnRNP) and a cytoplasmic mRNA-binding protein (mRNP), which may be stably bound to a translationally inactive subpopulation of mRNAs within the cytoplasm []. It is distributed in both, the nucleus and the cytoplasm, and binds to poly(A)+ RNA (mRNA or pre-mRNA). Although it is one of the major cellular proteins cross-linked by UV light to polyadenylated RNAs in vivo, Pub1 is nonessential for cell growth in yeast []. Pub1 also binds to T-rich single stranded DNA (ssDNA) []; however, there is no strong evidence implicating Pub1 in the mechanism of DNA replication. Pub1 contains three RNA recognition motifs (RRMs) and a GAR motif (glycine and arginine rich stretch) that is located between RRM2 and RRM3. |
