| Primary Identifier | IPR034511 | Type | Domain |
| Short Name | SRSF6_RRM1 |
| description | This entry represents the RNA recognition motif 1 (RRM1) of SRSF6, also termed pre-mRNA-splicing factor SRp55, which is an essential splicing regulatory serine/arginine (SR) protein that preferentially interacts with a number of purine-rich splicing enhancers (ESEs) to activate splicing of the ESE-containing exon []. It is the only protein from HeLa nuclear extract or purified SR proteins that specifically binds B element RNA after UV irradiation. SRSF6 may also recognize different types of RNA sites. For instance, it does not bind to the purine-rich sequence in the calcitonin-specific ESE, but binds to a region adjacent to the purine tract []. Moreover, cellular levels of SRSF6 may control tissue-specific alternative splicing of the calcitonin/ calcitonin gene-related peptide (CGRP) pre-mRNA []. SRSF6 contains two N-terminal RNA recognition motifs (RRMs), followed by a C-terminal SR domain rich in serine-arginine dipeptides. |
