| Primary Identifier | IPR034520 | Type | Domain |
| Short Name | SRSF1_RRM1 |
| description | This entry represents the RNA recognition motif 1 (RRM1) of SRSF1 (also knwon as ASF/SF2). SRSF1 is a member of the SR (serine/arginine) protein family of splicing regulators. Besides mRNA splicing, it is also involved in regulating mRNA transcription, stability and nuclear export, NMD, and translation, as well as protein sumoylation. It has been identified as a proto-oncogene. SRSF1 contains two RRMs, which are required for efficient RNA binding and splicing []. The SR protein family is a group of mRNA metabolism regulators. Its members have a modular domain with one or two RNA-recognition motifs (RRMs) and a C-terminal RS domain comprising multiple Arg-Ser dipeptide repeats. There are 12 human SR proteins []. |
