| Primary Identifier | IPR034799 | Type | Domain |
| Short Name | PTBP2_RRM3 |
| description | This entry represents the RNA recognition motif 3 (RRM3) of polypyrimidine tract-binding protein 2 (PTBP2).PTBP2 is a homologue of PTB (PTBP1), a splicing repressor factor implicated in the control of alternative exon selection during mRNA processing of many different transcribed genes, including its own pre-mRNA. PTBP2 is expressed at high levels in adult brain, muscle and testis []. PTB and PTBP2 bind to the same RNA sequences and have similar effects on alternative splicing events. However, differential expression of PTB and PTBP2 can lead to the generation of alternatively spliced mRNAs []. During neuronal differentiation, microRNA miR-124 downregulates PTB expression, which in turn leads to upregulation of PTBP2. Later in development, the expression of PTBP2 decreases and this leads to a second wave of alternative splicing changes characteristic of adult brain and essential for brain development []. |
