| Primary Identifier | IPR034834 | Type | Domain |
| Short Name | PRC_RRM |
| description | This entry represents the RNA recognition motif of PGC-1-related coactivator (PRC).PGC-1-related coactivator (PRC or PPRC1) was first identified as a transcriptional coactivator that shares structural and functional features with PGC-1alpha. It belongs to the PGC-1 family []. Similar to other PGC-1 members, PRC has a function in growth-regulated mitochondrial biogenesis. Different from other PGC-1 family members, PRC mRNA is induced by serum growth factors in the absence of de novoprotein synthesis, which place the PRC gene in a class of immediate early or primary response genes []. In mice germ line, knock-out of PRC causes early embryonic lethality []. PRC is also required for the induction of an inflammatory/stress response to multiple metabolic insults []. |
