| Primary Identifier | IPR034996 | Type | Domain |
| Short Name | HuR_RRM2 |
| description | This entry represents the RNA recognition motif 2 (RRM2) of HuR, also known as ELAV-like protein 1 (ELAV-1), the ubiquitously expressed Hu family member [, ]. HuR binds to AU-rich RNA element (ARE) in target mRNAs and stabilizes them against degradation. It also regulates the nuclear import of proteins []. It has a variety of biological functions mostly related to the regulation of cellular response to DNA damage and other types of stress. HuR has an anti-apoptotic function during early cell stress response []. HuR may be important in muscle differentiation, adipogenesis, suppression of inflammatory response and modulation of gene expression in response to chronic ethanol exposure and amino acid starvation [].Like other Hu proteins, HuR contains three RNA recognition motifs (RRMs). RRM1 and RRM2 may cooperate in binding to an AU-rich RNA element (ARE). RRM3 may help to maintain the stability of the RNA-protein complex, and might also bind to poly(A) tails or be involved in protein-protein interactions []. |
