| Primary Identifier | IPR035002 | Type | Domain |
| Short Name | PTBP2_RRM1 |
| description | This entry represents the RNA recognition motif 1 (RRM1) of PTBP2, also known as nPTB, highly homologous to polypyrimidine tract binding protein (PTB) and perhaps specific to the vertebrates []. Both PTB and PTBP2 are alternative splicing regulators []. Unlike PTB, PTBP2 is enriched in the brain and in some neural cell lines []. Interestingly, PTB directly suppresses expression of nPTB in nonneuronal cells by a mechanism that involves exon repression and mRNA silencing via nonsense-mediated decay (NMD) []. PTBP2 contains four RNA recognition motifs (RRMs). |
