| Primary Identifier | IPR034209 | Type | Domain |
| Short Name | PUF60_RRM1 |
| description | This entry represents the RNA recognition motif 1 (RRM1) of PUF60 (also known as FIR). PUF60 is an essential splicing factor that functions as a poly-U RNA-binding protein required to reconstitute splicing in depleted nuclear extracts. Its function is enhanced through interaction with U2 auxiliary factor U2AF65 []. PUF60 also controls human c-myc gene expression by binding and inhibiting the transcription factor far upstream sequence element (FUSE)-binding-protein (FBP), an activator of c-myc promoters []. It has anti-inflammatory properties, playing a role in the host response []. PUF60 contains two central RNA recognition motifs (RRMs) and a C-terminal U2AF (U2 auxiliary factor) homology motifs (UHM) that harbours another RRM and binds to tryptophan-containing linear peptide motifs (UHM ligand motifs, ULMs) in several nuclear proteins []. |
