| Primary Identifier | IPR037367 | Type | Domain |
| Short Name | Rex2_DEP_1 |
| description | PREX2 functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein []. It contains an N-terminal RhoGEF domain, two DEP and PDZ domains.This entry represents the first DEP domain of PREX2. |
