| Primary Identifier | IPR037705 | Type | Domain |
| Short Name | PI3K-C2-alpha_dom |
| description | This entry represents the catalytic domain of PI3K-C2-alpha, which is a Class II phosphoinositide-3-kinase (PI3K) that generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). It plays key roles in clathrin assembly and clathrin-mediated membrane trafficking [], insulin signaling [], and vascular smooth muscle contraction [].PI3Ks can be divided into three main classes (I, II, and III), defined by their substrate specificity, regulation, and domain structure. Class I PI3Ks are the only enzymes capable of converting PtdIns(4,5)P2 to the critical second messenger PtdIns(3,4,5)P3. Class II PI3Ks preferentially use PtdIns as a substrate to produce PtdIns(3)P, but can also phosphorylate PtdIns(4)P. They function as monomers and do not associate with any regulatory subunits. Class II enzymes contain an N-terminal Ras binding domain, a lipid binding C2 domain, a PI3K homology domain of unknown function, an ATP-binding cataytic domain, a Phox homology (PX) domain, and a second C2 domain at the C terminus [, ]. |
