| Primary Identifier | IPR000418 | Type | Domain |
| Short Name | Ets_dom |
| description | Transcription factors are protein molecules that bind to specific DNAsequences in the genome, resulting in the induction or inhibition of genetranscription []. The ets oncogene is such a factor, possessing a region of 85-90 amino acids known as the ETS (erythroblast transformation specific) domain [, , ]. This domain is rich inpositively-charged and aromatic residues, and binds to purine-rich segmentsof DNA. The ETS domain has been identified in other transcription factorssuch as PU.1, human erg, human elf-1, human elk-1, GA binding protein, anda number of others [, , ].It is generally localized at the C terminus of the protein,with the exception of ELF-1, ELK-1, ELK-3, ELK-4 and ERF where it is found atthe N terminus.NMR-analysis of the structure of the Ets domains revealed that it contains three α-helices (1-3)and four-stranded β-sheets (1-4) arranged in the order α1-β1-β2-α2-α3-β3-β4 forming awinged helix-turn-helix (wHTH) topology []. The third α-helix isresponsive to contact to the major groove of the DNA. Different members of the Ets family proteinsdisplay distinct DNA binding specificities. The Ets domains and the flanking amino acid sequencesof the proteins influence the binding affinity, and the alteration of asingle amino acid in the Ets domain can change its DNA binding specificities. |
