| Primary Identifier | IPR030496 | Type | Family |
| Short Name | RelB |
| description | RelB is a component of the NF-kappa-B RelB-p50 complex and the RelB-p52 complex []. It is best known for its roles in lymphoid development and noncanonical signalling [], but it seems to be linked to many distinct processes. Among others, RelB may have a role in suppressing inflammation []and has been shown to negatively regulate osteoblast differentiation and bone formation [].NF-kappaB is a pleiotropic transcription factor present in almost all cell types. It is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RelA/p65, RelB, NFKB1/p50, c-Rel and NFKB2/p52 []. Each individual NF-kappaB subunit, and perhaps each dimer, carries out unique functions in regulating transcription. Dimer-specific functions can be conferred by selective protein-protein interactions with other transcription factors, coregulatory proteins, and chromatin proteins []. |
