| Primary Identifier | IPR037971 | Type | Domain |
| Short Name | Ank3_Death |
| description | ANK-3, also called anykyrin-G (for general or giant), is found in neurons and at least one splice variant has been shown to be essential for propagation of action potentials as a binding partner to neurofascin and voltage-gated sodium channels []. It is required for maintaining axo-dendritic polarity [], and may be a genetic risk factor associated with bipolar disorder []. ANK-3 contains an N-terminal membrane-binding domain containing ANK repeats, a spectrin-binding domain and a C-terminal Death domain. This entry represents the Death domain of ANK-3. DDs (Death domains) are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including CARD (Caspase activation and recruitment domain), DED (Death Effector Domain), and PYRIN. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [, ]. |
