| Primary Identifier | IPR036407 | Type | Homologous_superfamily |
| Short Name | DM_DNA-bd_sf |
| description | This entry represents the DM DNA-binding domain superfamily.DMRT genes encode a conserved family of transcription factors that share a unique DNA binding motif, the DM domain []. This domain was first discovered in the doublesex proteins of Drosophila melanogaster []. In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides []. These proteins are believed to function as transcription factors on downstream sex-determination genes, especially on neuroblast differentiation and yolk protein genes transcription [, ]. The DM domain binds DNA as a dimer, allowing the recognition of pseudopalindromic sequences [, , ]. The NMR analysis of the DSX DM domain []revealed a novel zinc module containing 'intertwined' CCHC and HCCC zinc-binding sites with an α-helical fold. The recognition of the DNA requires the carboxy-terminal basic tail which contacts the minor groove of the target sequence. |
