| Primary Identifier | IPR000703 | Type | Family |
| Short Name | Proenkphlin_A |
| description | Vertebrate endogenous opioid neuropeptides are released by post-translational proteolytic cleavage of precursor proteins. The precursors consist of the following components: a signal sequence that precedes a conserved region of about 50 residues; a variable-length region; and the sequence of theneuropeptide itself. Three types of precursor are known: preproenkephalin A (gene PENK), which is processed to produce 6 copies of Met-enkephalin, plus Leu-enkephalin; preproenkephalin B (gene PDYN), which is processed toproduce neoendorphin, dynorphin, leumorphin, rimorphin and Leu-enkephalin; and prepronocipeptin (gene PNOC), whose processing produces nociceptin(orphanin FQ) and two other potential neuropeptides.Sequence analysis reveals that the conserved N-terminal region of theprecursors contains 6 cysteines, which are probably involved in disulphidebond formation. It is speculated that this region might be important for neuropeptide processing [].The primary structure of rat preproenkephalin is highly similar to those of bovine and human preproenkephalins, and contains four copies of Met-enkephalin, one of Leu-enkephalin, one of Met-enkephalin-Arg6-Gly7-Leu8, and one of Met-enkephalin-Arg6-Phe7 [, ]. |
