| Primary Identifier | IPR042743 | Type | Domain |
| Short Name | STK10_STKc |
| description | STKs (serine/threonine-protein kinases) catalyse the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK10/LOK, also called polo-like kinase kinase 1 in Xenopus (xPlkk1) [], is highly expressed in lymphocytes and is responsible in regulating leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion []. It plays a role in regulating the CD28 responsive element in T cells [], and may also function as a regulator of polo-like kinase 1 (Plk1), a protein which is overexpressed in multiple tumour types []. |
