| Primary Identifier | IPR042763 | Type | Domain |
| Short Name | ST17B_STKc |
| description | This entry represents the catalytic domain of ST17B (Serine/threonine-protein kinase 17B), also known as DRAK2 [].STKs (serine/threonine-protein kinases) catalyse the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. DRAK2 has been implicated in inducing or enhancing apoptosis in beta cells, fibroblasts, and lymphoid cells, where it is highly expressed [, ]. It is involved in regulating many immune processes including the germinal centre (GC) reaction, responses to thymus-dependent antigens, activated T cell survival, memory T cell responses [, , , , ]. It may be involved in the development of autoimmunity []. |
