| Primary Identifier | IPR033702 | Type | Domain |
| Short Name | PLK1_cat |
| description | Serine/Threonine Kinases (STKs) catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Polo-like kinases (PLKs) are serine/threonine kinases that play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes [].PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. Its localization changes during mitotic progression; associating first with centrosomes in prophase, with kinetochores in prometaphase and metaphase, at the central spindle in anaphase, and in the midbody during telophase [, , ]. It carries multiple functions throughout the cell cycle through interactions with differrent substrates at these specific subcellular locations []. PLK1 is overexpressed in many human cancers and is associated with poor prognosis [, , ].This entry represents the N-terminal catalytic kinase domain of PLK1. |
