| Primary Identifier | IPR000779 | Type | Family |
| Short Name | IL-2 |
| description | T-Lymphocytes regulate the growth and differentiation of certain lymphopoietic andhaemopoietic cells through the release of various secreted protein factors [].These factors, which include interleukin-2 (IL2), are secreted by lectin- or antigen-stimulatedT-cells, and have various physiological effects. IL2 is a lymphokine that induces theproliferation of responsive T-cells. In addition, it acts on some B-cells, via receptor-specificbinding [], as a growth factor and antibody production stimulant []. Theprotein is secreted as a single glycosylated polypeptide, and cleavage of a signal sequenceis required for its activity []. Solution NMR suggests that the structure of IL2 comprises abundle of 4 helices (termed A-D), flanked by 2 shorter helices and several poorly-definedloops. Residues in helix A, and in the loop region between helices A and B, are important forreceptor binding. Secondary structure analysis has suggested similarity to IL4 and granulocyte-macrophage colony stimulating factor (GMCSF) []. |
