| Primary Identifier | IPR030146 | Type | Family |
| Short Name | FSCN1 |
| description | Fascins are actin cross-linking proteins that function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles [].In humans there are three fascin isoforms identified: fascin1-3. Fruit flies only have one fascin, also known as protein singed, which links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis [].This entry represents fascin-1 (FSCN1) from mammals and its homologues from Xenopus laevis and Drosophila melanogaster. FSCN1 plays a role in stress fibre organisation and focal adhesion disassembly []. In humans, FSCN1 serves as a tumour marker that is highly expressed in numerous types of cancer, including lymphomas. It is important for migration and metastasis of tumour cells []. |
