| Primary Identifier | IPR022110 | Type | Domain |
| Short Name | CASC1_C |
| description | This domain can be found at the C terminus of CASC1.The CAncer Susceptibility Candidate 1 (CASC1) gene is expressed in lung tissues, and is a strong candidate for the pulmonary adenoma susceptibility 1 (Pas1) locus, the major determinant of strain variation in lung tumour susceptibility []. There appears to be a strong correlation between functional polymorphism of CASC1 and lung tumour suspectibility in mice [].Different mouse strains fall into two genotype groups (susceptible and intermediate) according to differences in the 60th codon of the CASC1 gene []. The mouse CASC1 gene shares 81% similarity with the human equivalent; the role of CASC1 in human lung-cancer risk may nevertheless differ from that in mice [, ]. |
