| Primary Identifier | IPR030546 | Type | Family |
| Short Name | E41L2 |
| description | This entry represents band 4.1-like protein 2 []. It shares protein sequence similarity with Band 4.1 protein. Its function is not clear.Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating physical properties of the membrane, such as mechanical stability and de-formability, by stabilising spectrin-actin interactions [, , ]. It is required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase [].The protein has been shown to associate with the nuclear mitotic apparatus, the contractile apparatus and tight junctions. Defects in this protein can cause elliptocytosis type 1 and hereditary pyropoikilocytosis.Note: Band 4.1 and Band 7 () proteins refer to human erythrocyte membrane proteins separated by SDS polyacrylamide gels and stained with coomassie blue []. |
