| Primary Identifier | IPR022819 | Type | Family |
| Short Name | Poxvirus_Bcl-2-like |
| description | This family represents a group of Poxvirus Bcl-2-like proteins that function as immunomodulators to evade the host innate immune response through the inhibition of apoptosis or blocking the activation of pro-inflammatory transcription factors, such as interferon (IFN) regulatory factor-3 (IRF-3) and nuclear factor-kappaB (NF-kappaB) []. These proteins have low sequence identity but high structural similarity to the eukaryotic Bcl-2 protein family. They have a Bcl-2 fold which comprises a central hydrophobic α-helix that is surrounded by an additional layer of 6-7 amphipathic α-helices []. Included in this family are proteins B14 [], A52 [, ], A46 [], C6 [], K7, N1, and N2 []. Protein N1 has the unusual dual ability of modulating apoptosis and inflammatory signalling []. Protein K7, in addition to its anti-inflammatory activity, forms a complex with RNA helicase DDX3 and antagonises interferon-beta promoter induction []. |
