| Primary Identifier | IPR009179 | Type | Family |
| Short Name | E3L |
| description | RNA-binding protein E3 from Vaccinia virus (E3L) is a dsRNA-binding protein capable of inhibiting protein kinase R and is an effective IRF3 and -7 phosphorylation inhibitor []. The C terminus of E3L binds to double-stranded RNA (dsRNA), while the N terminus of E3L is required for the additional regulation of eIF2alpha phosphorylation [].Protein E3 from Variola virus is also included in this family. It plays a role in the inhibition of multiple cellular antiviral responses activated by dsRNA, such as inhibition of PKR activation, apoptosis, and IFN-mediated antiviral activities []. |
