| Primary Identifier | IPR034133 | Type | Domain |
| Short Name | Chemokine_CC_DCCL |
| description | This domain is found in a subgroup of CC chemokines based on the presence of a DCCL motif involving the two N-terminal cysteine residues. This subgroup includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by blocking progression through the cell cycle; including Exodus-1 (also known as CCL20, MIP-3alpha, LARC, ST38 (mouse)), Exodus-2 (also known as CCL21, SLC, 6-Ckine, TCA4, CKbeta9), and Exodus-3 (also known as CCL-19, ELC, MIP-3beta, CKbeta11) []. Exodus-3 was shown to inhibit the growth of human breast cancer cells in vivo in a mouse model []. Exodus-1, -2, and -3 were all shown to significantly inhibit chronic myelogenous leukemia progenitor cell proliferation []. Exodus-2 and -3 show potent immunotherapeutic activity toward solid tumours []. They are found only in vertebrates. |
