| Primary Identifier | IPR033275 | Type | Family |
| Short Name | MARCH-like |
| description | This entry includes human E3 ubiquitin-protein ligase MARCH proteins (MARCH1/2/3/4/5/8/9/11), and virus proteins (MIR1, MIR2, LAP and VIE1) that share homology with the MARCH proteins [, ]. Human MARCH1 mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies []. Virus MIR1 has been shown to function as an E3 ubiquitin ligase for immune recognition-related molecules []. |
