| Primary Identifier | IPR010197 | Type | Family |
| Short Name | OSB_synthase_MenC_2 |
| description | This entry describes the enzyme o-succinylbenzoic acid synthetase (menC) that is involved in one of the steps of the menaquinone biosynthesis pathway. It takes SHCHC and makes it into 2-succinylbenzoate. Also included are enzymes with the common name of N-acylamino acid racemase (NAAAR, or the more general term, racemase / racemase family), which refers to the enzyme's industrial application as a racemase that catalyses the racemization of N-acylamino acids, and not to its biological function as o-succinylbenzoic acid synthetase []. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building blocks for antibiotics, herbicides, and drugs. Most members of this group of o-succinylbenzoate synthases are proteins from low GC Gram-positive bacteria and archaea. menC/NAAAR is a member of the enolase superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion [, ]. |
