| Primary Identifier | IPR000802 | Type | Family |
| Short Name | Arsenical_pump_ArsB |
| description | Arsenic is a toxic metalloid whose trivalent and pentavalent ions inhibita variety of biochemical processes. Operons that encode arsenic resistancehave been found in multicopy plasmids from both Gram-positive andGram-negative bacteria []. The resistance mechanism is encoded from a singleoperon, which houses an anion pump. The pump has two polypeptide components:a catalytic subunit (the ArsA protein), which functions as anoxyanion-stimulated ATPase; and an arsenite export component (the ArsB protein),which is associated with the inner membrane []. The ArsA and ArsB proteinsare thought to form a membrane complex that functions as ananion-translocating ATPase.The ArsB protein is distinguished by its overall hydrophobic character,in keeping with its role as a membrane-associated channel. Sequenceanalysis reveals the presence of 13 putative transmembrane (TM) regions. |
