| Primary Identifier | IPR015445 | Type | Family |
| Short Name | TBP-like |
| description | TATA-Box binding protein (TBP) is a general factor that plays a central role in the activation of eukaryotic genes transcribed by RNA polymerase II [, ]. TBP binds specifically to the TATA-box promoter element, which lies close to the position of transcription initiation.TBP-like factors (TLF; also called TLP, TRF, TRP) are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which arepart of the basal transcription machinery. Yet, in contrast to TBPs, TLFs seem not to interact with the TATA-box and even have a negative effect on the transcription of TATA-containing promoters. Recent results indicate that TLFs are involved in the transcription via TATA-less promoters [, , , , , ].This entry refers to TATA box-binding protein-like proteins. |
