| Primary Identifier | IPR035654 | Type | Domain |
| Short Name | LepA_IV |
| description | Elongation factor 4, also known as ribosomal back-translocase LepA, is required for accurate and efficient protein synthesis under certain stress conditions. Its function is not clear. However, it may act as a fidelity factor of the translation reaction, by catalysing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly [, ]. Elongation factor 4 binds to ribosomes in a GTP-dependent manner. The eukaryotic homologue is known as GUF1 and promotes protein synthesis in chloroplasts and mitochondria [].EF4 has six domains, of which four (I, II, III, and V) are homologous to corresponding domains in EF-G [, , ]. This entry represents domain IV of EF4, homologous to domain V of EF-G. |
