| Primary Identifier | IPR010971 | Type | Family |
| Short Name | UbiH/COQ6 |
| description | This entry represents a family of FAD-dependent hydroxylases (monooxygenases), which are all believed to act in the aerobic ubiquinone biosynthesis pathway []. In Escherichia coli, three enzyme activities have been described: UbiI, UbiH and UbiF []. UbiH and UbiF are similar to one another and form the basis of this subfamily. UbiI (also known as visC) []is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (also known as visB) []. Several other species appear to have three homologues in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homologue in this subfamily (COQ6, []) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF. |
