| Primary Identifier | IPR010016 | Type | Family |
| Short Name | KipI_fam |
| description | Kinase A inhibitor KipI was first identified as a potent inhibitor of the autophosphorylation reaction of kinase A (KipA) and its reverse reaction, but does not inhibit phosphate transfer to the Spo0F response regulator once kinase A is phosphorylated. KipI is an inhibitor of the catalytic domain of kinase A affecting the ATP/ADP reactions and not the phosphotransferase functions of this domain. The inhibition is noncompetitive with respect to ATP [].KipI forms a complex with KipA. The KipI-KipA complex shares protein structure and sequence similarity with the carboxyltransferase (CT) domain of urea amidolyase from K. lactis, but residues that are important for CT catalysis are not conserved in KipA and KipI. Therefore, the KipA-KipI complex is unlikely to have CT activity []. |
