| Primary Identifier | IPR023028 | Type | Family |
| Short Name | Mannitol_1_phos_5_DH |
| description | Mannitol dehydrogenases catalyse the NAD-dependent reduction of mannitol-1-phosphates as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The PTS facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glycolytic intermediates []. Mannitol 2-dehydrogenase catalyses the NAD-dependent reduction of mannitol to fructose [].Several dehydrogenases have been shown []to be evolutionary related, including mannitol-1-phosphate 5-dehydrogenase () (gene mtlD), mannitol 2-dehydrogenase () (gene mtlK); mannonate oxidoreductase () (fructuronate reductase) (gene uxuB); Escherichia coli hypothetical proteins ydfI and yeiQ; and yeast hypothetical protein YEL070w.This entry represents the mannitol-1-phosphate 5-dehydrogenase family, which catalyses the reactionD-mannitol-1-phosphate + NAD+=>beta-D-fructose-6-phosphate + H++ NADH |
