| Primary Identifier | IPR036672 | Type | Homologous_superfamily |
| Short Name | TCL1_MTCP1_sf |
| description | Two related oncogenes, TCL-1 and MTCP-1 , are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28 [].TCL-1 is an all-beta protein consisting of an eight-stranded antiparallel beta barrel with a novel topology. The barrel consists of two four-stranded β-meander motifs, related by a two fold axis and connected by a long loop. The structure of MTCP-1 is very similar, diverging only in regions that are either flexible and/or involved in crystal packing [, ]. |
