| Primary Identifier | IPR033508 | Type | Family |
| Short Name | Aminopeptidase_A |
| description | Aminopeptidase A (or glutamyl aminopeptidase, (); MEROPS identifier M01.003) is an aminopeptidase that releases Glu and Asp residues from the N-termini of proteins and peptides []. Although broadly distributed, the enzyme is particularly abundant in the brush borders of intestinal enterocytes and kidney []. The enzyme is activated by calcium and inhibited by metal chelators [, ]. Aminopeptidase A converts angiotensin II to angiotensin III, but in vivo conversion has only been shown in thebrain []. However, angiotensin III is a major effector peptide in control of vasopressin release and therefore control of blood pressure []. This has led to the development of therapeutic agents for the control of hypertension, such as the orally administered RB150, which is an aminopeptidase A inhibitor []. Aminopeptidase A is also abundantly expressed in the placenta and may have a role in preventing angiotensin II passing between mother and foetus []. In the kidney, monoclonal antibodies to aminopeptidase A induce albuminuria []. |
