| Primary Identifier | IPR036667 | Type | Homologous_superfamily |
| Short Name | PTS_IIB_sorbose-sp_sf |
| description | Bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains []. The Man family is unique in several respects among PTS permease families:It is the only PTS family in which members possess a IID protein.It is the only PTS family in which the IIB constituent is phosphorylated on a histidyl rather than a cysteyl residue.Its permease members exhibit broad specificity for a range of sugars, rather than being specific for just one or a few sugars.The mannose permease of Escherichia coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N-acetylglucosamine, and other sugars. Other members of this can transport sorbose, fructose and N-acetylglucosamine. The active site histidine receives a phosphate group from the IIA subunit and transfers it to the substrate []. This entry represents the IIB components of this family of PTS transporters []. The structure of this component has three layers (alpha/beta/alpha) with parallel β-sheet of six strands. |
