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Protein Domain : ARF GTPase-activating protein GIT1, C-terminal

Primary Identifier  IPR022018 Type  Domain
Short Name  GIT1_C
description  This entry represents the C-terminal domain of the ARF GTPase-activating protein GIT1. GIT1 is an ArfGAP and scaffolding protein regulating cell adhesion and migration []. To perform this function, it localises p21-activated kinase (PAK) and PAK-interactive exchange factor to focal adhesions. Its activation is regulated by interaction between its paxillin-binding C-terminal and the LD motifs of paxillin. The C-terminal folds into a four helix bundle.

0 Child Features

0 Parent Features

11 Protein Domain Regions