| Primary Identifier | IPR035840 | Type | Domain |
| Short Name | Chimaerin_SH2 |
| description | Chimaerin is a family of GTPase activating proteins for the small G-protein Rac. Chimaerin family members have been implicated in development, neuritogenesis and cancer []. Several isoforms have been found: alpha1-chimaerin (formerly known as n-chimaerin) and alpha2-chimaerin are alternatively spliced products of a single gene, as are beta1- and beta2-chimaerin []. Both alpha-chimaerin isoforms share identical diacylglycerol-binding (C1) and RacGAP domains. Alpha1- and beta1-chimerin have a relatively short N-terminal region that does not encode any recognizable domains, whereas alpha2- and beta2-chimerin both include a functional SH2 domain that can bind to phosphotyrosine motifs within receptors. It has been shown that alpha-chimaerins inactivate Rac and the alpha1-chimaerin isoform contributes to dendritic retraction events in cultured neurons. Alpha2-chimaerin is an effector for EphA4 in cortical and spinal motor circuits []. Beta2-Chimaerin mediates axonal pruning in the hippocampus [].This entry represents the SH2 domain of alpha2-chimerin and beta2-chimerin. |
