| Primary Identifier | IPR035860 | Type | Domain |
| Short Name | JAK2_SH2 |
| description | Jak2 is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constitutively associated with the prolactin receptor []and is required for responses to gamma interferon []. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis []. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites [, , ]. |
