| Primary Identifier | IPR024956 | Type | Domain |
| Short Name | tRNAHis_GuaTrfase_cat |
| description | The Thg1 protein from Saccharomyces cerevisiae is responsible for adding a GMP residue to the 5' end of tRNA His []. The catalytic domain of Thg1 contains a RRM (ferredoxin) fold palm domain, just like the viral RNA-dependent RNA polymerases, reverse transcriptases, family A and B DNA polymerases, adenylyl cyclases, diguanylate cyclases (GGDEF domain) and the predicted polymerase of the CRISPR system []. Thg1 possesses an active site with three acidic residues that chelate Mg++ cations []. Thg1 likely catalyses polymerisation using a similar mechanism to the 5'-3' polymerases [, ]. |
