| Primary Identifier | IPR036992 | Type | Family |
| Short Name | Contactin-1 |
| description | Contactins are cell adhesion molecules that belong to the immunoglobulin superfamily and are involved in neural development []. They usually consist of six N-terminal Ig domains, four fibronectin type III domains, and a C-terminal glycophosphatidylinositol (GPI)-anchor to the extracellular part of the cell membrane [].Contactin-1 (CNTN1) is expressed by a diversity of neurons and contributes to the formation and function of neuronal connections []. Contactin-1 regulates both myelin formation and organisation of nodal and paranodal domains in the central []and peripheral nervous system []. It plays a relevant role in cerebellar ontogenesis []and cerebral cortex development []. Contactin-1 contributes to the invasion and metastasis of several tumours [, ]. |
