| Primary Identifier | IPR022339 | Type | Family |
| Short Name | MHC_II-assoc_invar_chain |
| description | The CD74 antigen (also known as H-2 class II histocompatibility antigen gamma chain, MHC class II-associated invariant chain, Ia antigen-associated invariant chain, or Ii) plays a key role in MHC class II antigen processing: it stabilises peptide-free class II alpha/beta heterodimers in a nonameric (α-β-gamma)3 complex after their synthesis, and directs transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place []. CD74/Ii is a single-pass type II membrane protein containing a thyroglobulin type-1 domain. The structure of the trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii has been determined by NMR []. The molecule is cylindrical in shape and reveals conserved molecular surfaces that may mediate interactions between Ii and class II molecules []. |
