| Primary Identifier | IPR022325 | Type | Family |
| Short Name | TNFR_16 |
| description | The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain -a region that contains many cysteine residues arranged in a specific repetitive pattern []. The cysteines allow formation of an extended rod-like structure, responsible for ligand binding []. Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences []. Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [, ]. TNFRs are widely distributed and play important roles in many crucial biological processes, such as lymphoid and neuronal development, innate and adaptive immunity, and maintenance of cellular homeostasis []. Drugs that manipulate their signalling have potential roles in the prevention and treatment of many diseases, such as viral infections, coronary heart disease, transplant rejection, and immune disease []. TNF receptor 16 (also known as nerve growth factor receptor (NGFR) and p75NTR)) acts as a low affinity receptor for neurotrophins. The receptor mediates a variety of contradictory cellular functions, including cell survival or apoptosis, promotion or inhibition of axonal growth, and facilitation or attenuation of proliferation, depending on the cellular context []. The receptor may also play a role in inflammation, and has been implicated in the pathogenesis of asthma []. A single partial match was also found, , a translated human cDNA sequence that fails to match motifs 1 and 2. |
