Primary Identifier | IPR046357 | Type | Homologous_superfamily |
Short Name | PPIase_dom_sf |
description | This superfamily represents the peptidyl-prolyl cis-trans isomerase domain found in a wide range of proteins, including trigger factor [, ], FK506-binding proteins [, ], proteins from the parvulin family such as Par10 from E.coli, Pin1 and Par14 from human or Pin from plants [], chaperone SurA [, ]and foldase protein PrsA []. This domain catalyses cis/trans isomerization of peptidyl-prolyl bonds, which is often rate-limiting for protein folding.This domain consists of a flattened β-barrel of four/six-stranded, antiparallel sheets, surrounded by four/six α-helices. |