| Primary Identifier | IPR035575 | Type | Family |
| Short Name | Fli-1 |
| description | The FLI-1 protein participates in regulation of cellular differentiation, proliferation, and survival [, ]. The Fli-1 gene was initially described in Friend virus-induced erythroleukemias as a site for virus integration. It is highly expressed in hematopoietic tissues and at lower level in lungs, heart, and ovaries. Fli-1 is a proto-oncogene implicated in Ewing's sarcoma and erythroleukemia [, ]. Members of this subfamily are potential targets for cancer therapy []. The Fli-1 proto-oncogene is a member of the ETS family of winged helix-turn-helix transcription factors that bind a purine-rich consensus sequence GGA(A/T) [].This entry also includes DNA-binding protein D-ETS-3, a drosophila protein which shows very high sequence homology to FLI-1 and contains and almost identical DNA binding domain []. |
