| Primary Identifier | IPR029814 | Type | Family |
| Short Name | Fra2 |
| description | Transcription factor activator protein (AP)-1, comprising Jun (c-Jun, JunB, and JunD) and Fos (c-Fos, FosB, Fra1, and Fra2) family members, plays a central role in regulating gene transcription in various biological processes []. Fos protein family members form stable heterodimerswith Jun proteins and thereby enhance their DNAbindingactivity []. This entry reprsents fos-related antigen 2 (Fra2), which is implicated in TGFbeta signalling. Fra2 is a positive regulator of bone and matrix formation in mice and humans []. Fra2 is a STAT5 (signal transducers and activators of transcription 5) target gene regulated by IL-2 in human CD4 T cells []. It may also play an important role in the pathogenesis of systemic sclerosis, an autoimmune disease of unknown etiology that affects the skin and a variety of internal organs including the lungs, heart, and gastrointestinal tract []. |
