| Primary Identifier | IPR029815 | Type | Family |
| Short Name | Fra1 |
| description | Transcription factor activator protein (AP)-1, comprising Jun (c-Jun, JunB, and JunD) and Fos (c-Fos, FosB, Fra1, and Fra2) family members, plays a central role in regulating gene transcription in various biological processes []. Fos protein family members are involved in rodent fibroblasts transformation []. Fos protein family members form stable heterodimers with Jun proteins and thereby enhance their DNA-bindingactivity [].This entry represents fos-related antigen 1 (Fra1). It is an activator of bone matrix formation []and can negatively regulate pulmonary fibrosis in vivo []. It is overexpressed in breast cancer cells and may be a possible biomarker for prognosis of breast cancer []. |
