| Primary Identifier | IPR009212 | Type | Family |
| Short Name | Methylthioribose_kinase |
| description | Members of this family are 5-methylthioribose kinases () that catalyse phosphorylation of 5-methylthioribose (MTR), a step in the recycling of methionine from 5'-methylthioadenosine, a co-product of polyamine biosynthesis. The preceding step of methylthioadenosine (MTA) hydrolysis to MTR is catalysed by 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase.Bacillus subtilis protein MtnK (formerly YkrT) []and Klebsiella pneumoniae protein MtrK []have been experimentally characterised. K. pneumoniae MtrK expression is regulated by methionine [].As this enzyme is absent in mammals, it has been considered a target for rational drug design. |
